期刊
SCIENCE
卷 352, 期 6285, 页码 565-569出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad3369
关键词
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资金
- Top Institute Food and Nutrition, Wageningen [TiFN GH001]
- Netherlands Organization for Scientific Research [NWO-VIDI 864.13.013, ZonMW-VIDI 917.14.374, ZonMW-VIDI 016.136308]
- CardioVasculair Onderzoek Nederland [CVON 2012-03]
- University of Groningen
- Fundacion Alfonso Martin Escudero
- European Research Council (ERC) under the European Union [2012-322698]
- ERC [310312, 637640]
- VIB
- FWO
- IWT (Agency for Innovation by Science and Technology)
- Rega institute for Medical Research
- KU Leuven
- NIH
- JDRF
- CCFA
- EU [305564, 305479]
- [259867]
- [FP7 METACARDIS HEALTH-F4-2012-305312]
- European Research Council (ERC) [637640] Funding Source: European Research Council (ERC)
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.
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