期刊
SCIENCE
卷 352, 期 6287, 页码 812-816出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad5252
关键词
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资金
- Alexander Graham Bell Canada Graduate Scholarship [Natural Sciences and Engineering Research Council of Canada (NSERC)]
- Fonds de la Recherche en Sante du Quebec
- Canadian Institutes of Health Research (CIHR)
- NSERC
- Human Frontier Science Program [RGY0076/2012]
- Douglas Foundation
- McGill University
- Canadian Fund for Innovation (CFI)
- Canadian Research Chair (CRC Tier 2)
- CIHR
- Swiss National Science Foundation
- Inselspital
- University of Bern
Rapid eye movement sleep (REMS) has been linked with spatial and emotional memory consolidation. However, establishing direct causality between neural activity during REMS and memory consolidation has proven difficult because of the transient nature of REMS and significant caveats associated with REMS deprivation techniques. In mice, we optogenetically silenced medial septum gamma-aminobutyric acid-releasing (MSGABA) neurons, allowing for temporally precise attenuation of the memory-associated theta rhythm during REMS without disturbing sleeping behavior. REMS-specific optogenetic silencing of MSGABA neurons selectively during a REMS critical window after learning erased subsequent novel object place recognition and impaired fear-conditioned contextual memory. Silencing MSGABA neurons for similar durations outside REMS episodes had no effect on memory. These results demonstrate that MSGABA neuronal activity specifically during REMS is required for normal memory consolidation.
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