期刊
SCIENCE
卷 352, 期 6291, 页码 1326-1329出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf6463
关键词
-
资金
- Swedish Research Council (VR) (Medicine and Health)
- Swedish Cancer Society
- Wallenberg Scholar and Soderberg Foundation
- VR (Linnaeus Center in Developmental Biology for Regenerative Medicine) [2011-3116, 2011-3318]
- Swedish Foundation for Strategic Research (Successful Research Leaders program)
- European Union (EU) (NeuroStemCellRepair)
- European Union (EU) (DDPDGENES)
- Karolinska Institutet (KI) (SFO Stem Cells and Regenerative Medicine)
- VR
- StratNeuro
- Hjarnfonden
- EU FP7/Marie Curie Actions
- European Molecular Biology Organization (ALTF) [596-2014]
- EU FP7 (Marie Curie Actions, EMBOCOFUND) [GA-2012-600394]
- Petrus and Augusta Hedlunds Foundation
- Novo Nordisk Foundation
- European Research Council (ERC) (SECRET-CELLS)
- EU (PAINCAGE)
- ERC [293544]
- Wellcome Trust [100269/Z/12/Z, 108/26/Z/15/2, 108/26/2/15/Z]
- National Natural Science Foundation of China [31411013]
- UK Biotechnology and Biological Sciences Research Council [BB/L003236/1]
- Human Frontier Science Program
- ERC (BRAINCELL) [261063]
- VR (STARGET)
- EU (FP7/DDPDGENES)
- European Committee for Treatment and Research of Multiple Sclerosis
- VR [2015-03558]
- EU (EP7/Marie Curie Integration Grant, EPIOPC)
- Swedish Society of Medicine
- Ake Wiberg Foundation
- Clas Groschinsky Foundation
- Petrus och Augusta Hedlunds Foundation
- BBSRC [BB/L003236/1] Funding Source: UKRI
- MRC [G0800575] Funding Source: UKRI
- Swedish Research Council [2015-03558] Funding Source: Swedish Research Council
- Alzheimers Research UK [ART-EG2009A-1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/L003236/1] Funding Source: researchfish
- Medical Research Council [G9708005, G0800575] Funding Source: researchfish
- Novo Nordisk Fonden [NNF14OC0010695, NNF15OC0015964] Funding Source: researchfish
- Wellcome Trust [100269/Z/12/Z] Funding Source: researchfish
- European Research Council (ERC) [293544] Funding Source: European Research Council (ERC)
Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single -cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra' oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra' population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据