期刊
SCHIZOPHRENIA RESEARCH
卷 176, 期 2-3, 页码 171-176出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2016.06.005
关键词
Dopamine; Psychosis; Childhood adversity; PET; At risk mental state; social defeat
类别
资金
- Medical Research Council (MRC) [G0700995]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust
- King's College London
- MRC [MR/J012149/1, G1100583, MR/K013807/1, MR/K004867/1, G0600972, G0700995, MC_U120097115] Funding Source: UKRI
- Medical Research Council [G0700995, 1116129, G0501775, G1100583, G0600972, MR/K004867/1, MR/J012149/1, MR/K013807/1, MC_U120097115] Funding Source: researchfish
- National Institute for Health Research [NIHR-CS-011-001, CL-2015-18-005, ACF-2014-18-010, RP-PG-0606-1049, NF-SI-0512-10110] Funding Source: researchfish
Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animalmodels suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective of this study was to examine the relationship between adversity in childhood and striatal dopamine function in early adulthood. Secondary objectives were to compare exposure to childhood adversity and striatal dopamine function in young people at ultra high risk (UHR) of psychosis and healthy volunteers. Sixty-seven young adults, comprising 47 individuals at UHR for psychosis and 20 healthy volunteers were recruited from the same geographic area and were matched for age, gender and substance use. Presynaptic dopamine function in the associative striatum was assessed using 18F-DOPA positron emission tomography. Childhood adversity was assessed using the Childhood Experience of Care and Abuse questionnaire. Within the sample as a whole, both severe physical or sexual abuse (T63= 2.92; P = 0.005), and unstable family arrangements (T57= 2.80; P = 0.007) in childhood were associated with elevated dopamine function in the associative striatum in adulthood. Comparison of the UHR and volunteer subgroups revealed similar incidence of childhood adverse experiences, and there was no significant group difference in dopamine function. This study provides evidence that childhood adversity is linked to elevated striatal dopamine function in adulthood. (C) 2016 The Authors. Published by Elsevier B.V.
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