Domino Reactions of Pyrazol-5-amines with Arylglyoxals and Malononitrile

Domino reactions of 3-methylpyrazol-5-amine and 1-phenyl-3-methylpyrazol-5-amine with arylglyoxal hydrates and malononitrile in alcohol proceed regioselectively and lead to the formation of 6-aminopyrazolo[3,4-b]pyridine-5-carbonitrile.