Synthesis of Aminobismethylenephosphonic Acids on a Platform of p-tert-Butylthiacalix[4]arene in 1,3-alternate Configuration

Aminobismethylenephosphonic acids on a platform of p-tert-butylthiacalix[4] arene were obtained by reacting macrocyclic amines with phosphorous acid and formaldehyde under acid catalysis. Free phenol hydroxy groups on the lower rim of p-tert-butylthiacalix[4] arene were found to inhibit the interaction with the amino moieties of the macrocycle. In the case of amino derivatives of thiacalix[4] arene containing no hydroxy groups the reaction led to the formation of target compounds in good yields.