期刊
RNA BIOLOGY
卷 14, 期 5, 页码 460-470出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1189069
关键词
CRISPR; excludon; non-coding RNA; riboswitch; thermosensor; transcriptome
资金
- European Research Council [BacCellEpi-670823]
- ERA-NET Infect-ERA ProAntiLis
- Investissements d'Avenir BACNET [ANR-10-BINF-0201]
- IBEID [ANR-10-LABX-62-01]
- Fondation le Roch Les Mousquetaires
- Fondation pour la Recherche Medicale [FRM-AJE20131128944]
- Inserm ATIP-Avenir
- Mairie de Paris (Program Emergences - Recherche medicale)
- Investissements d'Avenir MemoLife [ANR-10-LABX-54]
The model opportunistic pathogen Listeria monocytogenes has been the object of extensive research, aiming at understanding its ability to colonize diverse environmental niches and animal hosts. Bacterial transcriptomes in various conditions reflect this efficient adaptability. We review here our current knowledge of the mechanisms allowing L. monocytogenes to respond to environmental changes and trigger pathogenicity, with a special focus on RNA-mediated control of gene expression. We highlight how these studies have brought novel concepts in prokaryotic gene regulation, such as the excludon' where the 5-UTR of a messenger also acts as an antisense regulator of an operon transcribed in opposite orientation, or the notion that riboswitches can regulate non-coding RNAs to integrate complex metabolic stimuli into regulatory networks. Overall, the Listeria model exemplifies that fine RNA tuners act together with master regulatory proteins to orchestrate appropriate transcriptional programmes.
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