期刊
RNA BIOLOGY
卷 14, 期 9, 页码 1108-1123出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1191737
关键词
DNA methylation; epigenetics; methylcytidine; RNA methylation; tRNA
资金
- DFG [FOR1082]
A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyL-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, significant progress has characterized Dnmt2-related research. Here, we review this progress in its diverse facets including molecular evolution, structural biology, biochemistry, chemical biology, cell biology and epigenetics.
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