期刊
RNA BIOLOGY
卷 14, 期 8, 页码 1007-1017出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1227905
关键词
Alternative splicing; backsplicing; biogenesis; circularization; circRNA; ciRNA; exon skipping; noncoding RNA; pre-mRNA splicing; RNA stability
资金
- NIH [R00-GM104166, R35-GM119735]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM119735, R00GM104166] Funding Source: NIH RePORTER
Pre-mRNAs from thousands of eukaryotic genes can be non-canonically spliced to generate circular RNAs, some of which accumulate to higher levels than their associated linear mRNA. Recent work has revealed widespread mechanisms that dictate whether the spliceosome generates a linear or circular RNA. For most genes, circular RNA biogenesis via backsplicing is far less efficient than canonical splicing, but circular RNAs can accumulate due to their long half-lives. Backsplicing is often initiated when complementary sequences from different introns base pair and bring the intervening splice sites close together. This process is further regulated by the combinatorial action of RNA binding proteins, which allow circular RNAs to be expressed in unique patterns. Some genes do not require complementary sequences to generate RNA circles and instead take advantage of exon skipping events. It is still unclear what most mature circular RNAs do, but future investigations into their functions will be facilitated by recently described methods to modulate circular RNA levels.
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