期刊
RNA BIOLOGY
卷 14, 期 6, 页码 739-751出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1236169
关键词
Cajal body; coilin; non-coding RNAs; nuclear structure; nuclear bodies; nucleolus; phase separation; snoRNPs; snRNPs; telomerase
资金
- Wellcome Trust ISSF award [105621/Z/14/Z]
From their initial identification as nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the 2 structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.
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