期刊
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
卷 42, 期 1, 页码 91-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2015.08.010
关键词
Glucocorticoids; ANCA-associated vasculitis; Granulomatosis with polyangiitis; Microscopic polyangiitis
类别
资金
- Genentech [224513]
Glucocorticoids (GCs) have been the cornerstone of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) therapy since their advent in the 1950s. There is considerable variation in their use, both with respect to dose and duration. Given considerable treatment-related morbidity and mortality, refining the role of GCs is becoming increasingly important. This article discusses the current role of GCs in various phases of AAV treatment, including remission induction, maintenance therapy, treatment of relapses, and the use of local GCs. It discusses current controversies relating to GC use as well as research efforts that seek to reduce GC toxicity in AAV.
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