Metal-Organic Framework 199 Film as a Novel Adsorbent of Thin-Film Extraction

In this study, metal-organic framework (MOF)-199 was in situ grown on the surface of stainless steel mesh by a facile one-step hydrothermal synthesis strategy. A piece of the MOF-199-coated film was used as adsorbent in thin-film extraction. With octahedral shape, accessible macropores, and high surface area-to-volume, the MOF-199 coating exhibited excellent extraction ability and enhanced mass transfer rate toward six studied aldehydes. The proposed thin-film extraction-high-performance liquid chromatography method was applied successfully for the determination of aldehyde in human exhaled breath condensates of lung cancer patients and healthy people. The experimental conditions were optimized systematically. Under the optimal conditions, a wide linear application range was obtained with linear correlations (r) above 0.995; the limits of detection were from 1.3 to 20.3 nmol L-1. Reasonable recoveries were achieved between 74 and 120 %. The method possesses the potential advantages of simple setup, convenient operation, fast analysis and factory sensitivity, and little matrix interference. It supplies us with a new possibility for non-invasive monitoring of trace aldehyde metabolites in complex biological samples.