期刊
REVIEWS IN MEDICAL VIROLOGY
卷 27, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/rmv.1909
关键词
innate immunity; respiratory viruses; vitamin D
类别
资金
- Wellcome Trust [063717, 083567/Z/07/Z]
- Romanian Ministry of National Education, CNCS-UEFISCDI project [PN-II-ID-PCE-2012-4-0417]
- British Medical Association and Rosetrees Trust Grant
- European Research Council [233015]
- Medical Research Council Centre [G1000758]
- NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London
- Medical Research Council [G1000758] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0514-10053] Funding Source: researchfish
Vitamin D, in addition to its classical functions in bone homeostasis, has a modulatory and regulatory role in multiple processes, including host defense, inflammation, immunity, and epithelial repair. Patients with respiratory disease are frequently deficient in vitamin D, implying that supplementation might provide significant benefit to these patients. Respiratory viral infections are common and are the main trigger of acute exacerbations and hospitalization in children and adults with asthma and other airways diseases. Respiratory monocytes/macrophages and epithelial cells constitutively express the vitamin D receptor. Vitamin D, acting through this receptor, may be important in protection against respiratory infections. Whether the in vitro findings can be translated into a substantial in vivo benefit still remains uncertain. Here we review the in vitro data on the role of vitamin D in antiviral innate immunity, the data concerning the deficient levels of vitamin D in lung diseases, and the in vivo role of supplementation as protection against respiratory viral infections in healthy individuals and in patients with chronic respiratory diseases. Finally, we suggest ways of improving the effectiveness of vitamin D as an adjuvant in the prevention and treatment of acute respiratory infections.
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