期刊
CHIRALITY
卷 27, 期 3, 页码 228-234出版社
WILEY
DOI: 10.1002/chir.22417
关键词
separation of enantiomers; polysaccharide-based chiral selectors; basic chiral drugs; enantiomer elution order; effect of minor additives
资金
- Rustaveli Georgian National Science Foundation (RGNSF) [31/90]
The separation of enantiomers of 16 basic drugs was studied using polysaccharide-based chiral selectors and acetonitrile as mobile phase with emphasis on the role of basic and acidic additives on the separation and elution order of enantiomers. Out of the studied chiral selectors, amylose phenylcarbamate-based ones more often showed a chiral recognition ability compared to cellulose phenylcarbamate derivatives. An interesting effect was observed with formic acid as additive on enantiomer resolution and enantiomer elution order for some basic drugs. Thus, for instance, the enantioseparation of several -blockers (atenolol, sotalol, toliprolol) improved not only by the addition of a more conventional basic additive to the mobile phase, but also by the addition of an acidic additive. Moreover, an opposite elution order of enantiomers was observed depending on the nature of the additive (basic or acidic) in the mobile phase. Chirality 27:228-234, 2015. (c) 2015 Wiley Periodicals, Inc.
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