期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 234, 期 -, 页码 79-84出版社
ELSEVIER
DOI: 10.1016/j.resp.2016.08.005
关键词
Chronic obstructive pulmonary disease; Flow-volume loop; Rectangular area ratio; Dynamic hyperinflation; Exercise tolerance
Active expiration during exercise can increase intrathoracic pressure yielding concavity in the expiratory flow-volume loop in COPD. We investigated the relationship between this concavity and dynamic hyperinflation (DH). 17 COPD patients (FEVI: 38 +/- 10%pred, GOLD stage 3-4) and 12 healthy subjects performed cycle ergometer incremental exercise. Expiratory limb of the spontaneous flow-volume loop was analyzed breath-by-breath using a geometric approach (rectangular area ratio (RAR), Respir. Med., 104(3):389-96, 2010). RAR below 0.5 demonstrates expiratory limb concavity. DH was determined with serial inspiratory capacity maneuvers. 5 of 17 patients displayed little end-exercise concavity (RAR= 0.52 +/- 0.04, group LCONC). 12 patients had concavity at rest and end-exercise RAR reached 0.40 +/- 0.03 (group HCONC). Healthy subjects showed no concavity. End-exercise RAR correlated with resting FEV1%pred (R-2=0.81, P < 0.05). Group HCONC, compared to groups LCONC and H, reached significantly lower work rate, minute ventilation, and more dyspnea. DH inversely correlated with RAR (R-2=0.81, P <0.05). Detection of concavity in spontaneous flow-volume loops may help assess DH and exercise limitation in COPD. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据