期刊
RESPIRATORY MEDICINE
卷 118, 期 -, 页码 39-45出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2016.07.009
关键词
Antisynthetase syndrome; Jo-1 antibody; Antinuclear antibody; Interstitial lung disease; Dermatomyositis; Polymyositis
Background: Interstitial lung disease (ILD) is a common extra-muscular manifestation of antisynthetase (AS) syndrome. ILD prevalence is higher with anti-Jo-1 antibody positivity. Data on long-term outcomes in these patients are lacking. Methods: Over 15 years, we identified subjects with anti-Jo-1 positive AS syndrome and ILD. Demographics, pulmonary function testing (PFT), high-resolution computed tomography (HRCT), histopathology, and long-term survival were analyzed. Results: We identified 103 subjects (mean age 49.2 years, female predominance [70%]). The predominant myopathy was polymyositis (64%) followed by dermatomyositis (24%). In approximately half of studied subjects, AS syndrome and ILD were diagnosed within 6 months of each other. The majority had restriction on PFTs (98%). Non-specific interstitial pneumonia (NSIP) was the most common HRCT pattern (52%), followed by NSIP overlapping with organizing pneumonia (OP) (22%). Thirty-nine subjects had biopsy data. Ten-year survival was 68%. Multivariable analysis adjusted for age at ILD diagnosis, gender, FVC and DLCO, revealed that male gender (HR = 2.60, p = 0.04) and DLCO at presentation (HR = 0.94, p = 0.05) significantly predicted mortality. Conclusions: We present a large cohort of anti Jo-1 positive AS syndrome with ILD and note good overall survival. (C) 2016 Elsevier Ltd. All rights reserved.
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