Choline chloride based thiourea catalyzed highly efficient, eco-friendly synthesis and anti-bacterial evaluation of some new 6-amino-4-aryl-2,4-dihydro-3-phenyl pyrano [2,3-c] pyrazole-5-carbonitrile derivatives

In this study, a simple and highly efficient synthesis of some new 6-amino-4-aryl-2,4-dihydro-3-phenyl pyrano [2,3-c] pyrazole-5-carbonitrile derivatives by one-pot, four-component reaction with aryl aldehydes, hydrazine hydrate, ethyl benzoylacetate and malonitrile has been achieved. This method provides many advantages such as shorter reaction time with high yields, mild reaction conditions and environmental friendliness. Furthermore, all compounds were subsequently evaluated for their in-vitro antibacterial activity compared with cefazolin by minimum inhibitory concentration, all of these compounds were more active than cefazolin. The characterization of the synthesized compounds was established by melting point, IR, H-1 NMR and C-13 NMR spectra.