期刊
RESEARCH ON CHEMICAL INTERMEDIATES
卷 43, 期 4, 页码 2445-2455出版社
SPRINGER
DOI: 10.1007/s11164-016-2772-8
关键词
Multicomponent reactions; Pyran annulated heterocyclic scaffolds; Aqueous ethanol; Aspartic acid
资金
- Postgraduate and Research Centre, Dr. Rafiq Zakaria Campus, Maulana Azad College
Molecular diversity for the synthesis of pyran annulated heterocyclic scaffolds has been achieved from the multicomponent reaction of aldehyde, malonitrile and a third participant such as dimedone, barbituric acid and 3-methyl-1H-pyrazol-5(4H)-one. The reactions completed successfully using in situ-developed benzylidenemalononitriles via Knoevenagel reaction catalyzed by aspartic acid as a new efficient organo-catalyst in aqueous ethanol as a green medium at ambient conditions.
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