期刊
REPRODUCTIVE TOXICOLOGY
卷 61, 期 -, 页码 142-150出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.04.005
关键词
Phthalates; Follicular fluid; IVF parameters; Female reproduction; Endocrine disruptors
资金
- National Natural Science Foundation of China [81571508]
- Natural Science Foundation of Hubei Province [2014CFA069]
- Self-dependent Innovation Research Funding of Huazhong University of Science and Technology [2014KXYQ017]
Evidence from toxicological studies has demonstrated that phthalates can lead to reduced fertility through effects on folliculogenesis, oocyte maturation and embryonic development, but human data are limited. Concentrations of eight phthalate metabolites in 110 follicular fluid (FF) and urine samples collected from 112 women attending an infertility clinic in Wuhan, China were quantified, and correlations between paired matrices were explored. Associations between metabolite concentrations and in vitro fertilization (IVF) parameters were evaluated with multivariable models. Six metabolites were detected in >72.73% of the FF samples. MEHP and MBP were the dominant metabolites with a median level of 2.80 and 2.05 ng/mL, respectively. Significant correlations between the two matrices, urine and FF, were found for MEP (rs = 0.44), and MBP (rs = 0.22). FF and urinary metabolite concentrations were not associated with any IVF parameters. However, given the prevalence of phthalates exposure, further work is needed to elucidate the potential hazard on female reproduction. (C) 2016 Elsevier Inc. All rights reserved.
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