期刊
REPRODUCTIVE TOXICOLOGY
卷 59, 期 -, 页码 159-166出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2015.10.006
关键词
Reproduction; Fertility; Sperm counts; Ovulation; Implantation; Quaternary ammonium compounds; Disinfectants
资金
- Passport Foundation
- VA-MD College of Veterinary Medicine
Alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) are common ingredients in household bathroom and kitchen cleaning sprays. ADBAC + DDAC cause reproductive toxicity in mice. The aim of the present study was to investigate gender-specific reproductive effects from ADBAC + DDAC. Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of ADBAC + DDAC exposure. Dams exposed for 5 weeks to ADBAC + DDAC spent significantly less time in estrus. ADBAC + DDAC exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. Subfertility in mice from ADBAC + DDAC exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of ADBAC + DDAC exposure on human health is unclear, widespread exposure necessitates further consideration of their potential reproductive toxicity. (C) 2015 The Authors. Published by Elsevier Inc.
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