期刊
REPRODUCTIVE TOXICOLOGY
卷 61, 期 -, 页码 47-57出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.02.018
关键词
Organophosphate pesticides; Syncytiotrophoblast; Mitochondria; Progesterone; Endothelial NOS; Placenta
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnologicas [PIP 2009 0065]
- Agencia Nacional de Investigaciones Cientificas y Tecnicas (PICT) [1718]
- Universidad Nacional del Comahue [04-N021]
- Universidad Nacional del Comahue
- CONICET
The impact of environmental organophosphate (OP) pesticide exposure on respiratory complexes, enzymatic antioxidant defense activities, and oxidative damage markers in the syncytiotrophoblast and cytotrophoblast mitochondria was evaluated. Placenta] progesterone (PG) levels and endothelia] nitric oxide synthase (eNOS) expression were studied. Samples from women non-exposed (control group-CG) and women living in a rural area (rural group-RG) were collected during pesticide spraying season (RG-SS) and non-spraying season (RG-NSS). In RG-SS, the exposure biomarker placenta] carboxylesterase decreased and syncytiotrophoblast cytochrome c oxidase activity increased, while 4-hydroxynonenal levels decreased. PG levels decreased in RG-SS and in the RG. Nitric oxide synthase expression decreased in RG, RG-SS and RG-NSS. No significant changes in mitochondria] antioxidant enzyme activities were found. These results suggest that the alteration of syncytiotrophoblast mitochondria] complex IV activity and steroidogenic function may be associated to pesticide exposure. Reduction in placental PG and eNOS expression may account for low newborn weight in RG. (C) 2016 Elsevier Inc. All rights reserved.
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