期刊
REPRODUCTIVE SCIENCES
卷 23, 期 10, 页码 1282-1288出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719116637919
关键词
adolescent endometriosis; endometrioma; stem cells; progression
资金
- National Health and Medical Research Council of Australia [1042298]
- Victorian Infrastructure Support Program
Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with early-onset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.
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