期刊
RENAL FAILURE
卷 38, 期 8, 页码 1256-1266出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/0886022X.2016.1207053
关键词
Diabetes mellitus; nephropathy; oxidative stress; pomegranate seed oil; streptozotocin
资金
- Vice Research Chancellery, Mashhad University of Medical Sciences, Mashhad, Iran
Purpose: Oxidative stress due to hyperglycemia is a major cause of diabetes complications. The aim of this study was to evaluate the effects of pomegranate seed oil (PSO) on serum biochemical parameters, cardiomyopathy and nephropathy induced by diabetes mellitus.Method: W/A adult rats were divided into four groups (12 each): group 1, received saline (1mL/kg), group 2, received streptozotocin (STZ, 65mg/kg, a single dose as i.p.), groups 3 and 4, received STZ+PSO (0.4 and 0.8mL/kg, daily by gavage, respectively). After three weeks, six rats of each group and one week later the remaining animals were anesthetized, blood samples were taken for measuring serum biochemical parameters. Sections of heart and kidneys were used for histopathological studies and the remaining tissues were homogenized for measuring malondialdehyde (MDA) and total sulfhydryl groups.Results: Significant elevation of serum creatinine and urea, LDL, triglyceride, glucose levels as well as urine markers, MDA levels in tissue homogenates and a significant decrease in total thiol content and serum HDL were observed in STZ-treated group as compared with control group. PSO treatment resulted in a significant decrease in tissue MDA content, serum creatinine and urea levels as well as urine markers as compared with STZ-treated group. Lipid profile was ameliorated with PSO treatment. PSO also significantly reversed STZ-induced depletion in thiol content and histological abnormality. Effect of PSO was more specific at 28th than 21th days of study.Conclusion: The results showed that PSO has a protective effect against diabetes complications in rats.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据