期刊
REJUVENATION RESEARCH
卷 19, 期 6, 页码 478-+出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/rej.2015.1793
关键词
telomere length; TA-65; Astragalus; telomerase; randomized; placebo controlled trial
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 +/- 180 bp; p = 0.005), whereas subjects in the placebo group significantly lost TL (290 +/- 100 bp; p = 0.01). The high dose of TA-65 (1000 U) showed a trend of improvements in TL compared with that of the placebo group; however, the improvements did not reach statistical significance. TL changes in the low-dose group were similar for both median and 20th percentile TLs. The findings suggest that TA-65 can lengthen telomeres in a statistically and possibly clinically significant manner.
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