期刊
RADIOTHERAPY AND ONCOLOGY
卷 118, 期 3, 页码 521-527出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2016.02.019
关键词
Lung cancer; Radiation pneumonitis; Lung functional imaging; 4D-CT; Deformable image registration
资金
- Free to Breathe Young Investigator Research Grant
- NIH/NCI [R01 CA 093626]
- Japan Society for the Promotion of Science (JSPS) [127100000646]
Purpose: To investigate the hypothesis that CT ventilation functional image-based IMRT plans designed to avoid irradiating highly-functional lung regions are comparable to single-photon emission CT (SPECT) ventilation functional image-based plans. Methods and materials: Three IMRT plans were created for eight thoracic cancer patients using: (1) CT ventilation functional images, (2) SPECT ventilation functional images, and (3) anatomic images (no functional images). CT ventilation images were created by deformable image registration of 4D-CT image data sets and quantitative analysis. The resulting plans were analyzed for the relationship between the deviations of CT functional plan metrics from anatomic plan metrics (Delta(CT-anatomic)) and those of SPECT-functional plans (Delta(SPECT-anatomic)), and moreover for agreements of various metrics between the CT-functional and SPECT-functional plans. Results: The relationship between Delta(CT-anatomic) and Delta(SPECT-anatomic) was strong (e.g., R = 0.94; linear regression slope 0.71). The average differences and 95% limits of agreement between the CT-functional and SPECT-functional plan metrics (except for monitor units) for various structures were mostly less than 1% and 2%, respectively. Conclusions: This study demonstrated a reasonable agreement between the CT ventilation functional image-based IMRT plans and SPECT-functional plans, suggesting the potential for CT ventilation imaging to serve as a surrogate for SPECT ventilation in functional image-guided radiotherapy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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