期刊
RADIATION RESEARCH
卷 186, 期 4, 页码 367-376出版社
RADIATION RESEARCH SOC
DOI: 10.1667/RR14389.1
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资金
- Japanese Ministry of Health, Labour and Welfare (MHLW)
- U.S. Department of Energy (DOE)
- RERF [4-02]
- Grants-in-Aid for Scientific Research [15H04791] Funding Source: KAKEN
In a series of studies of atomic bomb survivors, radiationdose-dependent alterations in peripheral T-cell populations have been reported. For example, reduced size in naive T-cell pools and impaired proliferation ability of T cells were observed. Because these alterations are also generally observed with human aging, we hypothesized that radiation exposure may accelerate the aging process of the T-cell immune system. To further test this hypothesis, we conducted cross-sectional analyses of telomere length, a hallmark of cellular aging, of naive and memory CD4 T cells and total CD8 T cells in the peripheral blood of 620 atomic bomb survivors as it relates to age and radiation dose, using fluorescence in situ hybridization with flow cytometry. Since telomere shortening has been recently demonstrated in obesity-related metabolic abnormalities and diseases, the modifying effects of metabolic status were also examined. Our results indicated nonlinear relationships between T-cell telomere length and prior radiation exposure, i.e., longer telomeres with lower dose exposure and a decreasing trend of telomere length with individuals exposed to doses higher than 0.5 Gy. There were associations between shorter T-cell telomeres and higher hemoglobin Alc levels or fatty liver development. In naive and memory CD4 T cells, radiation dose and high-density lipoprotein (HDL) cholesterol were found to positively interact with telomere length, suggesting that the decreasing trend of telomere length from a higher radiation dose was less conspicuous in individuals with a higher HDL cholesterol. It is therefore likely that radiation exposure perturbs T-cell homeostasis involving telomere length maintenance by multiple biological mechanisms, depending on dose, and that long-term-radiationinduced effects on the maintenance of T-cell telomeres may be modified by the subsequent metabolic conditions of individuals. (C) 2016 by Radiation Research Society
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