期刊
PSYCHONEUROENDOCRINOLOGY
卷 68, 期 -, 页码 156-162出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2016.02.025
关键词
Oxytocin; Vasopressin; Vasopressin 1a receptor; Meadow vole; Social behavior; Lateral septum
资金
- National Science Foundation
- National Institutes of Health
- Eveillard Postdoctoral Fellowship at Smith College
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1257162] Funding Source: National Science Foundation
The peptide hormone oxytocin (OT) plays an important role in social behaviors, including social bond formation. In different contexts, however, OT is also associated with aggression, social selectivity, and reduced affiliation. Female meadow voles form social preferences for familiar same-sex peers under short, winter-like day lengths in the laboratory, and provide a means of studying affiliation outside the context of reproductive pair bonds. Multiple lines of evidence suggest that the actions of OT in the lateral septum (LS) may decrease affiliative behavior, including greater density of OT receptors in the LS of meadow voles that huddle less. We infused OT into the LS of female meadow voles immediately prior to cohabitation with a social partner to determine its effects on partner preference formation. OT prevented the formation of preferences for the partner female. Co-administration of OT with a specific OT receptor antagonist did not reverse the effect, but co-administration of OT with a specific vasopressin la receptor (V1 aR) antagonist did, indicating that OT in the LS likely acted through V1aRs to decrease partner preference. Receptor autoradiography revealed dense V1 aR binding in the LS of female meadow voles. These results suggest that the LS is a brain region that may be responsible for inhibitory effects of OT administration on affiliation, which will be important to consider in therapeutic administrations of OT. (C) 2016 Elsevier Ltd. All rights reserved.
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