期刊
PSYCHOLOGY HEALTH & MEDICINE
卷 22, 期 3, 页码 289-302出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13548506.2016.1199887
关键词
HIV; cytokines; inflammation; body mass index; neurocognition
资金
- National Institutes of Mental Health [R01 MH074368]
- National Institute of Alcohol Abuse and Alcoholism NIAAA [P01 AA019072]
- McKnight Brain Research Foundation
- NIAAA [U24AA02002]
- Brown University Center for Alcohol and Addiction Studies [P01 AA019072]
- Lifespan/Tufts/Brown Center for AIDS Research [P30 AI042853]
- NIDA [F31DA039810]
To determine the relationships among body mass index (BMI), and HIV-associated neurocognitive impairment and the potential mediating effects of inflammatory cytokines. Among the HIV-infected individuals (N=90) included in this study, obesity was associated with slower processing speed (=-.229, standard error (SE)=2.15, p=.033), compared to participants with a normal BMI, after controlling for psychosocial and HIV clinical factors. Serum concentrations of the interleukin-16 (IL-16) cytokine were significantly associated with slowed processing speed (=-.235, SE=1.62, p=.033) but did not mediate the relationship between obesity and processing speed These findings suggest that obesity may contribute to cognitive processing speed deficits in HIV-infected adults. Elevated concentrations of IL-16 are also associated with slowing, though the results suggest that obesity and IL-16 may exert independent effects.
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