期刊
PSYCHOLOGICAL MEDICINE
卷 46, 期 7, 页码 1391-1399出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291715002925
关键词
Antidepressants; commuting injuries; occupational injuries; public sector; workplace; work-related injuries
资金
- Academy of Finland [264944, 267727, 258598, 265174, 138255]
- Medical Research Council (MRC) [MR/K023241/1]
- Economic and Social Research Council (ESRC) [ES/L007509/1]
- MRC [K013351]
- National Heart, Lung and Blood Institute [HL36310]
- National Institute of Aging [AG034454]
- ESRC
- ESRC [ES/L007509/1, ES/J023299/1] Funding Source: UKRI
- MRC [MR/K013351/1, MR/K023241/1] Funding Source: UKRI
- Economic and Social Research Council [ES/J023299/1, ES/L007509/1] Funding Source: researchfish
- Medical Research Council [MR/K023241/1, MC_CF023241, MR/K013351/1] Funding Source: researchfish
Background. Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. Method. Antidepressant use and work-related injuries between 2000 and 2011 were measured among 66 238 employees (mean age 43.8 years, 80% female) using linkage to national records (the Finnish Public Sector study). We analysed data using time-dependent modelling with individuals as their own controls (self-controlled case-series design). Results. In 2238 individuals who had used antidepressants and had a work-related injury during a mean follow-up of 7.8 years, no increase in the risk of injury was observed in the beginning of antidepressant treatment. However, an increased injury risk was seen after 3 months of treatment (rate ratio, compared with no recent antidepressant use, 1.27, 95% confidence interval 1.10-1.48). This was also the case among those who had used only selective serotonin re-uptake inhibitors (n = 714; rate ratio 1.41, 95% confidence interval 1.08-1.83). Conclusions. Antidepressant use was not associated with an increased risk of work-related injury at the beginning of treatment. Post-hoc analyses of antidepressant trials are needed to determine whether long-term use of antidepressants increases the risk of work-related injury.
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