期刊
PSYCHO-ONCOLOGY
卷 26, 期 12, 页码 2101-2108出版社
WILEY
DOI: 10.1002/pon.4312
关键词
cancer; oncology; metastatic breast cancer; positive Affect; well-being; online
资金
- NCCIH NIH HHS [T32 AT003997] Funding Source: Medline
- NCI NIH HHS [K07 CA158008] Funding Source: Medline
- NIMH NIH HHS [R25 MH060482] Funding Source: Medline
BackgroundWe conducted a randomized pilot trial to examine the feasibility, acceptability, and preliminary efficacy of a 5week positive affect skills intervention (LILAC: lessons in linking affect and coping) for women with metastatic breast cancer. Additionally, we examined whether online delivery of the intervention would offer comparable benefits as in-person delivery. MethodsWomen with metastatic breast cancer (N=39) were randomized to an in-person intervention, online intervention, or in-person attention-matched control. Psychological well-being (depression [Center for Epidemiologic Studies Depression Scale], positive and negative affect [Differential Emotions Scale], cancer-specific quality of life [Multidimensional Quality of Life ScaleCancer Version]), and positive coping (mindfulness, positive-affect skill use, and self-compassion [Self-Compassion Scale: Short-Form]) were assessed at baseline, 1week post-intervention, and 1month post-intervention follow-up. ResultsThe LILAC intervention showed good feasibility, acceptability, and retention. Although the study was not adequately powered to detect between-group differences in change on preliminary efficacy outcomes, within-group comparisons revealed that LILAC participants (in-person and online combined) showed reductions in depression and negative affect by the 1month follow-up (d=-0.81). Notably, LILAC participants fell below the clinical threshold for depression (Center for Epidemiologic Studies Depression Scale=16) by the 1month follow-up (t[17]=-2.22, P=.04, d=-0.52), whereas control participants did not differ from threshold (t[9]=0.45, P=.66, d=0.14). ConclusionsThe LILAC intervention, regardless of delivery method, shows feasibility, acceptability, and preliminary efficacy for promoting psychological well-being in women with metastatic breast cancer. This research provides support for a larger randomized trial to test more definitively the potential benefits of LILAC. A strength of the LILAC intervention includes its innovative focus on positive affect. The efficacy of the online delivery suggests the potential for widespread Internet dissemination.
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