期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 250, 期 -, 页码 24-28出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2016.03.002
关键词
Parkinson's disease; Depression; Morphometry; Cortical thickness; Cortical area
资金
- National Natural Science Foundation of China [81301190, 81371519]
- National Science & Technology Pillar Program during the Twelfth Five Year Plan Period [2012BAI10B04]
- Zhejiang Provincial Natural Science Foundation [LZ14H180001]
Depression is a common occurrence in patients with Parkinson's disease (PD). Brain deficits may be the underlying cause of depression in PD. In the present study, we investigated whether morphometric alterations contribute to depression in PD. Seventeen depressed PD patients, 17 non-depressed PD patients and 45 normal controls were enrolled in the study. All subjects went through neurological and psychiatric clinical assessments. T1 weighted magnetic resonance imaging and surface-based morphometric analyses were performed to examine morphometric abnormalities in PD patients and their relationship to depression. We found that compared with normal controls, PD patients exhibited significantly decreased cortical thickness in the left precentral gyrus and the right postcentral gyms extending to the middle frontal gyms. Compared with non-depressed PD patients, depressed patients showed significantly increased cortical areas in the orbitofrontal regions and insula, which may imply white matter atrophy in these areas. The results of orbitofrontal and insula white matter atrophy are consistent with our previous finding that white matter integrity and functional connectivity are damaged in these regions in depressed PD patients, confirming their contribution to depression in PD. (c) 2016 Elsevier Ireland Ltd. All rights reserved.
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