期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 254, 期 -, 页码 119-126出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2016.06.008
关键词
ADHD; Voxel based morphometry; MRI; ADHD-inattentive type
资金
- NHMRC project [384419, 569533]
- Murdoch Childrens Research Institute
- Royal Children's Hospital
- Royal Children's Hospital Foundation
- Department of Paediatrics The University of Melbourne
- Victorian Government's Operational Infrastructure Support Program
- NHMRC Career Development Award [1004637]
Attention-deficit/hyperactivity disorder (ADHD) has reliably been associated with global grey matter reductions but local alterations are largely inconsistent with perhaps the exception of the caudate nucleus. The aim of this study was to examine local and global brain volume differences between typically developing children (TD) and children with a diagnosis of ADHD. We also addressed whether these parameters would differ between children with the ADHD-combined type (ADHD-C) and those with the ADHD-inattentive type (ADHD-I). Using an ROI approach caudate volume differences were also examined. 79 boys between the ages of 8 and 17 participated in the study. Of those 33 met diagnostic criteria for the ADHD-C and 15 for the ADHD-I subtype. 31 boys were included in the TD group. Structural magnetic resonance imaging data were analysed using voxel-based morphometry. The ADHD group had significantly lower global and local grey matter volumes within clusters in the bilateral frontal, right parietal and right temporal regions compared to TD. A significant group by age interaction was found for right caudate nucleus volume. No differences between the ADHD-C and ADHD-I groups were found. Right caudate nucleus volume and age are more strongly related in ADHD than in TD consistent with previous research. (C) 2016 Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据