期刊
PSYCHIATRY RESEARCH
卷 239, 期 -, 页码 301-307出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2016.03.038
关键词
Schizophrenia; Alcohol dependence; Drug dependence; Comorbidity
类别
资金
- Lundbeck A/S
- German Federal Ministry of Education and Research in the framework of the Research Association Public Health Saxony [01EG9732/7]
Little is known about the correlates of comorbid drug and alcohol dependence in people with schizophrenia outside the USA. We tested hypotheses that dependence on alcohol/drugs would be associated with more severe symptoms, and poorer psychosocial functioning and quality of life. The EuroSC Cohort study (N=1204), based in France, Germany and the UK, used semi-structured clinical interviews for diagnoses, and standardized tools to assess correlates. We used mixed models to compare outcomes between past-year comorbid dependence on alcohol/drugs, controlling for covariates and modelling both subject and country-level effects. Participants dependent on alcohol or drugs had fewer negative symptoms on PANSS than their non-dependent counterparts. However, those dependent on alcohol scored higher on PANSS general psychopathology than those who were not, or dependent only on drugs. People with schizophrenia dependent on drugs had poorer quality of life, more extrapyramidal side effects, and scored worse on Global Assessment of Functioning (GAF) than those without dependence. People with alcohol dependence reported more reasons for non-compliance with medication, and poorer functioning on GAF, though not on Global Assessment of Relational Functioning. In people with schizophrenia, comorbid dependence on alcohol or drugs is associated with impaired clinical and psycho social adjustment, and poorer quality of life. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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