期刊
PSYCHIATRY RESEARCH
卷 246, 期 -, 页码 89-94出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2016.09.033
关键词
Acute agitation; Schizophrenia; High-sensitivity C-reactive protein; White blood cell counts
类别
资金
- National Natural Science Foundation of China [81302855]
- Natural Science Foundation of Jiangsu Province, China [BK2012446]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [XMLX201513]
Increased levels of high-sensitivity C reactive protein (hsCRP) have been reported in schizophrenia, but to date, no study is designed to examine serum hsCRP in acutely agitated patients with schizophrenia, an extreme state that requires immediate diagnosis and medical treatment. Serum hsCRP levels were assessed in 32 clinically acutely agitated patients and 42 healthy control subjects matched for demographic properties. Further, serum hsCRP levels in acutely agitated patients were compared with control subjects and with the levels after the patients were treated with anti-psychiatric medications. Meanwhile, the influence of clinical subtypes, family history, and gender, as well as the levels of white blood cell (WBC) counts were also considered. In results, serum hsCRP levels were significantly higher in acutely agitated patients with schizophrenia than in healthy subjects. The elevation of serum hsCRP in patients was not affected by gender, family history (P>0.05), and clinical classification of schizophrenia (P>0.05). However, the elevation of hsCRP was suppressed by the medical treatment for schizophrenia with acute agitation (P<0.05). In addition, WBC counts, another inflammation-related indicator, were also increased significantly in acutely agitated patients compared with healthy subjects, consistent with the elevation of serum hsCRP. In conclusion, hsCRP is an important indicator of immune alterations in the pathogenesis of schizophrenia and has potential to be developed into a sensitive marker for the acute agitation in schizophrenia. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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