期刊
PROTEOMICS
卷 16, 期 11-12, 页码 1642-1651出版社
WILEY
DOI: 10.1002/pmic.201500490
关键词
3D imaging; Atherosclerosis; Lipids; MALDI; MS; Technology
资金
- Natural Sciences and Engineering Research Council of Canada
- Canadian Foundation for Innovation
- Canadian Institutes of Health Research (CIHR)
- CIHR Doctoral Award
- McGill University Systems Biology Training Program Studentship
- Fonds de recherche du Quebec - Sante (FRQS)
Three-dimensional MALDI imaging MS (IMS) is a growing branch of IMS still requiring developments in methodology and technology to make the technique routinely accessible. Many challenges are simply a matter of producing 3D reconstructions and interpreting them in a timely fashion. In this aim and using analysis of lipids from atherosclerotic plaques from a human carotid and mouse aortic sinuses, we describe 3D reconstruction methods using open-source software that provides high-quality visualization and rapid interpretation through multivariate segmentation of the 3D IMS data. Multiple datasets were generated for each sample and we provide insight into simple means to correlate the separate datasets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据