期刊
PROTEIN SCIENCE
卷 25, 期 3, 页码 546-558出版社
WILEY
DOI: 10.1002/pro.2858
关键词
glucose transporter; GLUT; SGLT; SWEET; alternating access; structural biology
资金
- Ministry of Science and Technology of China [2015CB910101, 2014ZX09507003006]
- International Early Career Scientist grant from the Howard Hughes Medical Institute
- Bayer Healthcare
- China Postdoctoral Science Foundation
Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental process for metabolism, growth, and homeostasis. Three families of secondary glucose transporters have been identified in human, including the major facilitator superfamily glucose facilitators GLUTs, the sodium-driven glucose symporters SGLTs, and the recently identified SWEETs. Structures of representative members or their prokaryotic homologs of all three families were obtained. This review focuses on the recent advances in the structural elucidation of the glucose transporters and the mechanistic insights derived from these structures, including the molecular basis for substrate recognition, alternating access, and stoichiometric coupling of co-transport.
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