期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 35, 期 12, 页码 2529-2536出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201509032
关键词
graft copolymer; polymeric drug micelles; coumarin; doxorubicin
资金
- National Natural Science Foundation of China [81371949, 81572114]
- Shanghai Scientific Technological Innovation Project [13411951200]
The end of linear m-PEG-OH was functionalized to provide m-PEG-CTA macro-RAFT agent. RAFT homopolymerization of tBHBMA was conducted to give PEG-b-PtBHBMA diblock copolymer, which initiated ROP of lactide directly. The obtained graft copolymer, PEG-b-(PtBA-g-PLA), was then esterified with 7-methoxycoumarin-3- carboxylic acid to afford PEG-b-(PtBA-g-PLA-COU) containing fluorescent dye molecule. PEG-b-(PAA-g-PLA-COU) amphiphilic graft copolymer was prepared by selective hydrolysis of PtBA segment. Finally, doxorubicin (DOX) was loaded into polymeric micelles aggregated by PEG-b-(PAA-g-PLA-COU). The drug loading content (DLC) and size of the obtained polymeric drug micelles containing fluorescent dye molecule was measured by UV-vis and DLS.
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