期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 107, 期 -, 页码 43-49出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2016.01.002
关键词
Elongase; Desaturase; LCPUFA; Lignoceric acid; Nervonic acid; Oleic acid
资金
- Alice Swenzon's Fund at South Alvsborg Hospital in Boras
- Swedbank's Fund at South Alvsborg Hospital in Boras
- Royal Society of Art and Sciences in Gothenburg
Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid's divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants. (C) 2016 Elsevier Ltd. All rights reserved.
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