期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 122, 期 -, 页码 54-63出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2015.12.006
关键词
Autophagy; Apoptosis; Cannabinoids; Cancer
资金
- Fundacao para a Ciencia e Tecnologia (FCT) [UID/Multi/04378/2013]
- FCT [SFRH/BPD/72958/2010, SFRH/BPD/98304/2013]
Autophagy, the self-digestion mechanism of the cells, is an evolutionary conserved catabolic process that targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation, which plays a crucial role in development and disease. Cannabinoids are active compounds of Cannabis sativa and the most prevalent psychoactive substance is Delta(9)-tetrahydrocannabinol (THC). Cannabinoid compounds can be divided in three types: the plant-derived natural products (phytocannabinoids), the cannabinoids produced endogenously (endocannabinoids) and the synthesized compounds (synthetic cannabinoids). Various studies reported a cannabinoid-induced autophagy mechanism in cancer and non-cancer cells. In this review we focus on the recent advances in the cannabinoid-induced autophagy and highlight the molecular mechanisms involved in these processes. (C) 2015 Elsevier Inc. All rights reserved.
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