期刊
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
卷 34, 期 2, 页码 367-371出版社
SCIENCE PRESS
DOI: 10.1007/s00343-015-4316-2
关键词
Talaromyces sp.; alkaloid; chiral separation; quantum chemical calculation; bioactivity
资金
- National Key Technology Research and Development Program for Agriculture [2012BAD32B09]
- National Natural Science Foundation of China [41106137, 41106136]
- Taishan Scholar Program of Shandong Province
- Chinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-QN209]
Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1b), that were identified for the first time. In addition, seven known compounds (2-8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
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