期刊
PROGRESS IN LIPID RESEARCH
卷 64, 期 -, 页码 69-84出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2016.08.003
关键词
Flippase; Floppase; Membrane asymmetry; Phosphatidylserine; Photoreceptor; Scramblase
资金
- Research Centre 'bioSYNergy' - University of Copenhagen's (Funds) Excellence Programme
- Danish National Research Foundation through the PUMPKIN Center of Excellence [DNRF85]
- Danish Council for Independent Research I Natural Sciences [DFF1323-00297]
- National Institutes of Health [GM106717, EY024207, NS093457]
Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus spontaneous flip-flop of polar lipids across membranes is very slow, even though it must occur rapidly to support diverse aspects of cellular life. Here we discuss the mechanisms by which rapid flip-flop occurs, and what role lipid flipping plays in membrane homeostasis and cell growth. We focus on conceptual aspects, highlighting mechanistic insights from biochemical and in silica experiments, and the recent, ground-breaking identification of a number of lipid scramblases. (C) 2016 Elsevier Ltd. All rights reserved.
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