期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 122, 期 2, 页码 122-130出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2015.11.005
关键词
Exercise; Mesenchymal stem cells; Osteoblasts; Osteocytes; Osteoclasts; Osteoporosis; Mechanical loading
资金
- Key Laboratory of Exercise and Health Sciences (Shanghai University of Sport), Ministry of Education
- National Natural Science Foundation of China [81170323]
With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise. (C) 2015 Elsevier Ltd. All rights reserved.
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