期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 120, 期 1-3, 页码 199-209出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2015.12.015
关键词
Cardiac nerves; Autonomic control; Atrial fibrillation; Ventricular tachycardia/fibrillation
资金
- US National Institutes of Health [R01 HL111600, R00HL105574, R01HL129136]
- American Heart Association [12SDG9010015]
Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias. (C) 2016 Elsevier Ltd. All rights reserved.
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