期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 283, 期 1824, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2015.2760
关键词
evolution; genomic imprinting; gene network; trans regulation
资金
- NSF [EF-0905606]
- Fondation Recherche Medicale [DEQ20150331703]
- MRC [G1001689] Funding Source: UKRI
- British Heart Foundation [PG/13/35/30236] Funding Source: researchfish
- Medical Research Council [G1001689] Funding Source: researchfish
Genomic imprinting is essential for development and growth and plays diverse roles in physiology and behaviour. Imprinted genes have traditionally been studied in isolation or in clusters with respect to cis-acting modes of gene regulation, both from a mechanistic and evolutionary point of view. Recent studies in mammals, however, reveal that imprinted genes are often co-regulated and are part of a gene network involved in the control of cellular proliferation and differentiation. Moreover, a subset of imprinted genes acts in trans on the expression of other imprinted genes. Numerous studies have modulated levels of imprinted gene expression to explore phenotypic and gene regulatory consequences. Increasingly, the applied genome-wide approaches highlight how perturbation of one imprinted gene may affect other maternally or paternally expressed genes. Here, we discuss these novel findings and consider evolutionary theories that offer a rationale for such intricate interactions among imprinted genes. An evolutionary view of these trans-regulatory effects provides a novel interpretation of the logic of gene networks within species and has implications for the origin of reproductive isolation between species.
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