期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 10, 页码 E1402-E1411出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1516953113
关键词
circadian misalignment; hypertension; inflammatory markers; night work; shift work
资金
- National Heart, Lung, and Blood Institute (NHLBI) [R01 HL094806]
- National Space Biomedical Research Institute through National Aeronautics and Space Administration [NCC 9-58]
- NHLBI [R01 HL094806, R01 HL118601, R00 HL102241]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01 DK099512]
- National Institute on Aging [P01AG009975]
- Clinical Translational Science Award [UL1RR025758]
- Brigham and Women's Hospital from the National Center for Research Resources
Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in humans. Here we show-by using two 8d laboratory protocols-that short-term circadian misalignment (12-h inverted behavioral and environmental cycles for three days) adversely affects cardiovascular risk factors in healthy adults. Circadian misalignment increased 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 3.0 mmHg and 1.5 mmHg, respectively. These results were primarily explained by an increase in blood pressure during sleep opportunities (SBP, +5.6 mmHg; DBP, +1.9 mmHg) and, to a lesser extent, by raised blood pressure during wake periods (SBP, +1.6 mmHg; DBP, +1.4 mmHg). Circadian misalignment decreased wake cardiac vagal modulation by 8-15%, as determined by heart rate variability analysis, and decreased 24-h urinary epinephrine excretion rate by 7%, without a significant effect on 24-h urinary norepinephrine excretion rate. Circadian misalignment increased 24-h serum interleukin-6, C-reactive protein, resistin, and tumor necrosis factor-a levels by 3-29%. We demonstrate that circadian misalignment per se increases blood pressure and inflammatory markers. Our findings may help explain why shift work increases hypertension, inflammation, and cardiovascular disease risk.
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