期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 13, 页码 3497-3502出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1516139113
关键词
bioactuator; stereolithography; tissue engineering; soft robotics
资金
- National Science Foundation (NSF) Science and Technology Center Emergent Behavior of Integrated Cellular Systems (EBICS) Grant [CBET-0939511]
- NSF [DGE-1144245]
- NSF Cellular and Molecular Mechanics and Bionanotechnology (CMMB) Integrative Graduate Education and Research Traineeship (IGERT) at UIUC [0965918]
Complex biological systems sense, process, and respond to their surroundings in real time. The ability of such systems to adapt their behavioral response to suit a range of dynamic environmental signals motivates the use of biological materials for other engineering applications. As a step toward forward engineering biological machines (bio-bots) capable of nonnatural functional behaviors, we created a modular light-controlled skeletal muscle-powered bioactuator that can generate up to 300 mu N (0.56 kPa) of active tension force in response to a noninvasive optical stimulus. When coupled to a 3D printed flexible bio-bot skeleton, these actuators drive directional locomotion (310 mu m/s or 1.3 body lengths/min) and 2D rotational steering (2 degrees/s) in a precisely targeted and controllable manner. The muscle actuators dynamically adapt to their surroundings by adjusting performance in response to exercise training stimuli. This demonstration sets the stage for developing multicellular bio-integrated machines and systems for a range of applications.
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