期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 47, 页码 13366-13371出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1605334113
关键词
genetics; education; longevity; prediction; polygenic score
资金
- Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6]
- Scottish Funding Council [HR030060]
- Biotechnology and Biological Sciences Research Council
- Medical Research Council
- University of Edinburgh as part of the cross-council Lifelong Health and Wellbeing initiative [MR/K026992/1]
- Age UK as part of the Disconnected Mind Project
- Estonian Genome Center of University of Tartu by the Targeted Financing from the Estonian Ministry of Science and Education [SF0180142s08]
- Development Fund of the University of Tartu [SP1GVARENG]
- European Regional Development Fund [3.2.0304.11-0312]
- FP7 [313010]
- MRC [MC_U147585819, G0400491, MC_UP_A620_1015, MC_PC_U127561128, MC_UU_12011/2, MC_U147585827] Funding Source: UKRI
- Chief Scientist Office [CZD/16/6/4] Funding Source: researchfish
- Medical Research Council [MC_UP_A620_1014, MC_U147585827, MC_U147585824, U1475000002, G0400491, MR/K026992/1, 1359901, MC_U147585819, MC_qA137853, MC_UU_12011/2, MC_UU_12011/1, 1201677, MC_PC_U127561128, U1475000001, 1578661, MC_UP_A620_1015] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, NF-SI-0508-10082, NF-SI-0507-10228, NF-SI-0514-10027] Funding Source: researchfish
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = similar to 17,000; UK Biobank, n = similar to 115,000; and the Estonian Biobank, n = similar to 6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with similar to 2.7% lower mortality risk for both mothers (total n(deaths) = 79,702) and similar to 2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
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