期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 33, 页码 9262-9267出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1605901113
关键词
paleontology; quantitative genetics; primates; neontology; dental variation
资金
- NIH National Center for Research Resources Grant [P51 RR013986]
- National Science Foundation Division of Behavioral and Cognitive Sciences Grant [0500179, 0616308, 0130277]
- Direct For Social, Behav & Economic Scie [0500179] Funding Source: National Science Foundation
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [0130277, 0616308] Funding Source: National Science Foundation
- Division Of Behavioral and Cognitive Sci [0500179] Funding Source: National Science Foundation
Developmental genetics research on mice provides a relatively sound understanding of the genes necessary and sufficient to make mammalian teeth. However, mouse dentitions are highly derived compared with human dentitions, complicating the application of these insights to human biology. We used quantitative genetic analyses of data from living nonhuman primates and extensive osteological and paleontological collections to refine our assessment of dental phenotypes so that they better represent how the underlying genetic mechanisms actually influence anatomical variation. We identify ratios that better characterize the output of two dental genetic patterning mechanisms for primate dentitions. These two newly defined phenotypes are heritable with no measurable pleiotropic effects. When we consider how these two phenotypes vary across neontological and paleontological datasets, we find that the major Middle Miocene taxonomic shift in primate diversity is characterized by a shift in these two genetic outputs. Our results build on the mouse model by combining quantitative genetics and paleontology, and thereby elucidate how genetic mechanisms likely underlie major events in primate evolution.
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