期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 5, 页码 E606-E615出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1513773113
关键词
vision; intrinsic activity; oscillations; connectivity; networks
资金
- Human Frontier Science Program Organization [RGP0070/2003]
- Volkswagen Foundation [I/79876]
- European Young Investigator award
- European Union [HEALTH-F2-2008-200728]
- Landes-Offensive zur Entwicklung Wissenschaftlich-okonomischer Exzellenz (Neuronale Koordination Forschungsschwerpunkt Frankfurt)
- Smart Mix Programme of the Netherlands Ministry of Economic Affairs
- Netherlands Ministry of Education, Culture and Science
- European Commission [604102]
- Netherlands Organization for Scientific Research [452-03-344, 016-071-079]
- Human Frontier Science Program Organization [RGP0070/2003]
- Volkswagen Foundation [I/79876]
- European Young Investigator award
- European Union [HEALTH-F2-2008-200728]
- Landes-Offensive zur Entwicklung Wissenschaftlich-okonomischer Exzellenz (Neuronale Koordination Forschungsschwerpunkt Frankfurt)
- Smart Mix Programme of the Netherlands Ministry of Economic Affairs
- Netherlands Ministry of Education, Culture and Science
- European Commission [604102]
- Netherlands Organization for Scientific Research [452-03-344, 016-071-079]
Intrinsic covariation of brain activity has been studied across many levels of brain organization. Between visual areas, neuronal activity covaries primarily among portions with similar retinotopic selectivity. We hypothesized that spontaneous interareal coactivation is subserved by neuronal synchronization. We performed simultaneous high-density electrocorticographic recordings across the dorsal aspect of several visual areas in one hemisphere in each of two awake monkeys to investigate spatial patterns of local and interareal synchronization. We show that stimulation-induced patterns of interareal coactivation were reactivated in the absence of stimulation for the visual quadrant covered. Reactivation occurred through both interareal cofluctuation of local activity and interareal phase synchronization. Furthermore, the trial-by-trial covariance of the induced responses recapitulated the pattern of interareal coupling observed during stimulation, i.e., the signal correlation. Reactivation-related synchronization showed distinct peaks in the theta, alpha, and gamma frequency bands. During passive states, this rhythmic reactivation was augmented by specific patterns of arrhythmic correspondence. These results suggest that networks of intrinsic covariation observed at multiple levels and with several recording techniques are related to synchronization and that behavioral state may affect the structure of intrinsic dynamics.
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