期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 48, 页码 13827-13832出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1609118113
关键词
allogeneic hematopoietic cell transplantation; graft-versus-host disease; autoimmunity; T-cell epitope; retina
资金
- fortune Programm of the Eberhard Karls Universitat Tubingen [1832-0-1]
- Deutsche Jose Carreras Leukamie Stiftung [DJS 08/04]
- Deutsche Krebshilfe [110465]
Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.
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